Ongoing Projects

Collaborative Research In Integrative Cancer Biology (NIH/NCI U01CA184902) (PI, Clarke, Georgetown University; Co-PI, Wang, Virginia Tech (Co-I, Xuan))

Early Detection of Ovarian Cancer with Special Focus on BRCA Carrier (Gray Foundation) (PI: Shih, JHU; PI of the Subaward to VT: Xuan, Virginia Tech)

Deep Machine Learning to Predict Protein Functions (Virginia Tech (Xuan) and University of Maryland School of Medicine (Neuwald))

Neuro-inspired Deep Learning Algorithms and Systems with Their Applications in Biomedical Research (Virginia Tech (Xuan) and UMBC (Choa))

Completed Projects

Uncovering Estrogen Receptor-Signaling Networks to Overcome Endocrine Resistance (NIH/NCI R01CA149653) (PI, Xuan, Virginia Tech; Co-PI, Clarke, Georgetown University)

Network-based Prediction of Antiestrogen Resistance in Breast Cancer (NIH/NCI R21CA139246) (PI, Xuan, Virginia Tech; Co-PI, Clarke, Georgetown University)

Transgenerational Effects of Maternal High Fat Diet During Pregnancy of Breast Cancer (NIH/NCI R01CA164384) (PI, Hilakivi-Clarke, Georgetown University; Co-PI, Xuan, Virginia Tech)

Center for Cancer Systems Biology: Integration of ER-related Signaling in Breast Cancer (NIH/NCI U54CA149147) (PI: Clarke, Georgetown University; Co-PI, Wang, Virginia Tech (Co-I, Xuan); Fox Chase Cancer Center)

Endocrine Therapy of Breast Cancer (DOD/CDMRP BC030280) (PI: Clarke, Georgetown University; Co-PI, Xuan, Virginia Tech)

Improved Diagnostics of the Muscular Dystrophies (NIH/NINDS R01NS29525-18A1 & 13A1) (PI, Hoffman, Children’s National Medical Center; Co-PIs, Xuan & Wang, Virginia Tech)

Polarization Cellular Imaging and Diagnosis (NASA NNJ05JC13C) (PI, Zhou, BATi ; Co-PI, Xuan, Virginia Tech)

Proteome Characterization Center: A Genoproteomics Pipeline for Cancer Biomarkers (NIH/NCI-CPTC U24CA160036) (Johns Hopkins Medical Institutions; Virginia Tech (Co-I, Xuan); Stanford U.; Memorial Sloan-Kettering Cancer Center; M.D. Anderson Cancer Center; U of Chicago)

Genomic and Proteomic Architecture of Atherosclerosis (NIH/NHLBI R01HL111362) (PI, Herrington, Wake Forest U; Co-PI, Wang, Virginia Tech (Co-I, Xuan); Johns Hopkins U, MIT)

caBIG In Silico Research Centers of Excellence (PI, Clarke, Georgetown University; Co-PI, Wang, Virginia Tech (Co-I, Xuan))

Comprehensive Analysis of Microarray Gene Expression Data (NIH/NCI CA109872) (Co-I, Xuan)

Bioengineering Research Partnerships: Molecular Analysis of Human Breast Cancer (NIH/NCI CA096483) (Co-I, Xuan)

Center of Excellence: Molecular Epidemiology and Mechanisms for Breast Carcinogenesis    (DOD/CDMRP DAMD17-03-1-0448) (Co-I, Xuan)

Computational Decomposition of Composite Molecular Signatures (NIH/NIBIB EB000830) (Co-I, Xuan)

Center of Excellence: Timing of Dietary Exposure and Breast Cancer Risk (NIH/NCI CA100970) (Co-I, Xuan)

Statistical Visualization of Localized Prostate Cancer (NIH RR12784) (Co-I, Xuan)